Biotech Blog

Thoughts, insights, and research on modern biotechnology, purification scale-up, and downstream processing.

Exploring the latest advancements in downstream processing and purification techniques for scalable mAb production.

Key considerations when transitioning TFF processes from pilot scale to commercial manufacturing.

A practical guide to identifying and resolving common binding and elution issues in Protein A steps.

Discussing the paradigm shift from empirical testing to designed quality in downstream processing.

The importance of orthogonal methods for viral safety in biomanufacturing.

How modifying downstream steps is necessary to purify complex bispecifics.

Strategies for effective aggregate removal and scale-up in IEX chromatography.