Biotech Blog

August 10, 2026

The Potential of AI in mAb Downstream Processing

Unlocking hybrid mechanistic-neural modeling, real-time peak cutting, and digital twins in biomanufacturing.

June 18, 2026

Continuous Chromatography & PAT in Biomanufacturing

Exploring multi-column countercurrent chromatography and real-time PAT for process intensification in modern biomanufacturing.

April 22, 2026

Host Cell Protein (HCP) Clearance Bottlenecks

Overcoming hitchhiker HCP impurities and implementing multimodal chromatography in biosimilar workflows.

February 14, 2026

Cleaning Validation in Multi-Product Facilities

Calculating MACO limits and executing TOC swab/rinse recovery verification in multi-product GMP bioprocess suites.

December 04, 2025

The Rise of Bispecific Antibodies

Modifying downstream purification workflows and multimodal resins to separate complex bispecific homodimer impurities.

October 12, 2025

The Future of Monoclonal Antibodies in Canada

Exploring downstream advancements and purification scale-up supporting Canada's expanding biomanufacturing infrastructure.

August 18, 2025

Implementing Quality by Design (QbD) in Biomanufacturing

Discussing the paradigm shift from empirical testing to designed quality space and critical process parameters in bioprocessing.

June 05, 2025

Viral Clearance Strategies in Downstream Processing

The importance of orthogonal methods, low pH inactivation, and nanofiltration for viral safety in biomanufacturing.

April 10, 2025

Scaling Up Tangential Flow Filtration

Key engineering considerations when transitioning ultrafiltration and diafiltration (UF/DF) from pilot scale to commercial manufacturing.

February 20, 2025

Troubleshooting Protein A Chromatography

A practical guide to identifying and resolving common binding, elution, and resin fouling issues in Protein A capture steps.

January 15, 2025

Optimizing Ion Exchange (IEX) Chromatography

Strategies for effective aggregate removal, charge variant resolution, and scale-up in IEX chromatography.